Representative before the EPO

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Simona Müller-Afraz has worked on the following 85 EPO patent applications which have been published in the last five years:

EP11715194

ARYL - /HETEROARYL - CYCLOHEXENYL - TETRAAZABENZO [E]AZULENES AS VASOPRESSIN ANTAGONISTS

IPC classification:
A61K 31/5517, A61P 9/00, A61P 15/00, A61P 25/00, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP11782588

PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/506, A61P 25/16, C07D 401/14, C07D 403/12, C07D 403/14, C07D 405/14, C07D 413/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP12706041

1,4 THIAZEPINES/SULFONES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/554, A61P 3/10, A61P 25/16, C07D 417/12, C07D 513/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12709616

1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/553, A61P 3/10, A61P 25/28, C07D 267/10, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP10782317

DIPHENYL AZEPINE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

IPC classification:
A61K 31/55, A61K 31/551, A61K 31/553, C07D 223/04, C07D 243/08, C07D 267/10
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12713127

1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/553, A61P 3/10, A61P 25/28, C07D 413/10, C07D 417/10
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12712669

1,3 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/5355, A61P 1/00, A61P 3/10, A61P 7/02, A61P 9/00, A61P 19/02, A61P 25/28, A61P 29/00, A61P 35/00, C07D 265/08, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12722112

1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/535, A61K 31/5355, A61P 25/28, C07D 265/08, C07D 413/10, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12724116

SPIRO-[1,3]-OXAZINES AND SPIRO-[1,4]-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/537, A61P 25/28, C07D 498/10
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP12725747

[1,3]OXAZINES

IPC classification:
A61K 31/5355, A61P 25/28, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP12725743

HALOGEN-ALKYL-1,3 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/5355, A61P 25/28, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12731448

CYCLOPROPYL-FUSED-1,3-THIAZEPINES AS BACE 1 AND/OR BACE 2 INHIBITORS

IPC classification:
C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12759458

N-(3-(2-AMINO-6,6-DIFLUORO-4,4A,5,6,7,7A-HEXAHYDRO-CYCLOPENTA[E][1,3]OXAZIN-4-YL)-PHENYL)-AMIDES AS BACE1 INHIBITORS

IPC classification:
A61K 31/536, A61P 25/28, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP12766618

BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS

IPC classification:
A61K 31/425, A61K 31/427, A61K 31/4436, A61K 31/4535, A61K 31/497, A61K 31/506, A61K 31/5377, A61P 35/00, C07D 277/34, C07D 277/38, C07D 417/04, C07D 417/08, C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12753948

PARP INHIBITORS

IPC classification:
A61K 31/167, A61K 31/495, A61P 35/00, C07C 317/44, C07D 237/18
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12761740

OXY-CYCLOHEXYL-4H,6H-5-OXA-2,3,10B-TRIAZA-BENZO[E]AZULENES AS V1A ANTAGONISTS

IPC classification:
A61K 31/553, A61P 9/12, C07D 498/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP12766670

CYCLOHEXYL-4H,6H-5-OXA-2,3,10B-TRIAZA-BENZO[E]AZULENES AS V1A ANTAGONISTS

IPC classification:
A61K 31/553, C07D 498/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP12766655

METHODS FOR THE PREPARATION OF 5-[2-[7-(TRIFLUOROMETHYL)-5-[4-(TRIFLUOROMETHYL)PHENYL]PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]ETHYNYL]-2-PYRIDINAMINE

IPC classification:
C07D 213/73, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP12173720

Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives

IPC classification:
A61K 31/4523, A61P 25/24, C07D 205/04, C07D 207/08, C07D 211/30, C07D 401/06, C07D 401/10, C07D 403/06, C07D 403/14, C07D 405/06, C07D 409/06, C07D 409/14, C07D 417/06, C07D 417/14, C07D 451/02, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12794308

2-(PHENYL OR PYRID-3-YL) AMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE

IPC classification:
A61K 31/506, A61P 25/16, C07D 403/12, C07D 405/14, C07D 413/12, C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP12791761

2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS KINASE LRRK2 MODULATORS FOR THE TREATMENT OF PARKINSON'S DISEASE

IPC classification:
A61K 31/505, A61K 31/506, A61P 25/16, C07D 239/47, C07D 239/48, C07D 401/12, C07D 403/12, C07D 405/12, C07D 405/14, C07D 413/12, C07D 487/04, C07D 491/107, C07D 498/08
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP12797828

FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2

IPC classification:
A61K 51/04
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12791198

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/506, A61K 31/5377, A61K 31/538, A61K 31/553, A61P 25/16, C07D 401/12, C07D 403/12, C07D 403/14, C07D 405/12, C07D 405/14, C07D 413/12, C07D 413/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP13701072

FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES

IPC classification:
A61K 31/535, A61K 31/5355, C07D 401/12, C07D 403/12, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP12797826

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/505, C07D 239/42, C07D 239/48
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP13718188

(3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES

IPC classification:
A61K 31/40, A61P 25/22, A61P 25/24, C07D 207/08
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP13718860

PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE

IPC classification:
A61K 31/506, A61P 25/16, C07D 471/04, C07D 487/04, C07D 498/04, C07D 498/20
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13720901

PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/506, A61P 25/16, C07D 403/12, C07D 403/14, C07D 407/14, C07D 413/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13723514

SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF

IPC classification:
A61K 31/444, A61P 25/28, C07D 401/12, C07D 401/14, C07D 405/14, C07D 487/08, C07D 491/107
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13725321

5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS

IPC classification:
A61K 31/541, A61P 25/28, C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13729285

PYRROLOPYRIMIDONE AND PYRROLOPYRIDONE INHIBITORS OF TANKYRASE

IPC classification:
A61K 31/519, A61P 35/00, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP13726532

AUTOIMMUNE ANTIBODIES

IPC classification:
A61K 39/395, G01N 33/574
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP13726537

PYRAZOLOPYRIMIDONE AND PYRAZOLOPYRIDONE INHIBITORS OF TANKYRASE

IPC classification:
A61K 31/437, A61K 31/519, A61P 35/00, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP13729367

PYRROLOPYRAZONE INHIBITORS OF TANKYRASE

IPC classification:
A61K 31/495, A61K 31/4985, A61P 35/00, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP13730887

DIFLUORO-HEXAHYDRO-CYCLOPENTAOXAZINYLS AND DIFLUORO-HEXAHYDRO-BENZOOXAZINYLS AS BACE1 INHIBITORS

IPC classification:
A61K 31/536, A61P 25/00, C07D 265/12, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13729366

PYRANOPYRIDONE INHIBITORS OF TANKYRASE

IPC classification:
C07D 491/052, C07D 491/147, C07D 491/153, C07D 495/14
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP13736570

ANTIPROLIFERATIVE BENZO [B]AZEPIN- 2 - ONES

IPC classification:
A61K 31/55, A61P 35/00, C07D 223/16, C07D 401/06, C07D 403/06, C07D 403/10, C07D 403/12, C07D 405/10, C07D 405/12, C07D 409/06, C07D 413/06, C07D 413/10, C07D 417/06, C07D 417/10, C07D 471/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP13747659

SUBSTITUTED HETERO-AZEPINONES

IPC classification:
A61K 31/553, A61K 31/554, C07D 267/14, C07D 281/10, C07D 498/10
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13745838

AZAHETEROCYCLES AS BIR2 AND/OR BIR3 INHIBITORS

IPC classification:
A61K 31/40, A61K 31/47, C07D 209/44, C07D 217/26, C07D 401/12, C07D 405/06, C07D 409/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP13766920

2-OXO-2,3,4,5-TETRAHYDRO-1 H-BENZO[B]DIAZEPINES AND THEIR USE IN THE TREATMENT OF CANCER

IPC classification:
A61K 31/5513, A61P 35/00, C07K 5/062
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP13774407

AZAINDOLINES

IPC classification:
A61K 31/437, A61P 35/00, C07D 471/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP13773766

AZAINDOLINES

IPC classification:
A61K 31/437, A61P 35/00, C07D 471/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP13771145

INDOLINES

IPC classification:
A61K 31/404, A61P 35/00, C07D 209/42
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP11718393

HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES

IPC classification:
A61K 31/5517, A61P 1/16, A61P 9/00, A61P 9/04, A61P 9/12, A61P 15/10, A61P 25/00, A61P 25/18, A61P 25/22, A61P 25/24, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP13782683

MGLU2/3 ANTAGONISTS FOR THE TREATMENT OF AUTISTIC DISORDERS

IPC classification:
A61K 9/00, A61K 31/00, A61K 31/444, A61K 31/519, A61P 25/00, A61P 25/28
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
GRANT OF PATENT INTENDED
EP13802359

DIMERIC COMPOUNDS

IPC classification:
A61K 31/551, A61P 35/00, C07D 243/12, C07D 401/14, C07D 403/12, C07D 403/14
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP14702209

3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS

IPC classification:
A61K 31/4439, A61P 25/16, A61P 25/28, C07D 401/14, C07D 405/04, C07D 405/14, C07D 471/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP14700493

FLUORO-[1,3]OXAZINES AS BACE1 INHIBITORS

IPC classification:
A61K 31/5355, A61P 25/28, C07D 413/10, C07D 413/12, C07D 413/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP14724824

PREDICTING RESPONSE TO EGFR INHIBITORS

IPC classification:
C12Q 1/68
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP11720065

2,5,6,7-TETRAHYDRO-[1,4]OXAZEPIN-3-YLAMINE OR 2,3,6,7-TETRAHYDRO-[1,4]OXAZEPIN-5-YLAMINE COMPOUNDS

IPC classification:
A61K 31/553, A61P 25/28, C07D 267/10, C07D 413/12, C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP14715908

BACE1 INHIBITORS

IPC classification:
A61K 31/5355, A61P 25/28, A61P 29/00, A61P 35/00, C07D 413/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP14722588

SYNTHESIS OF BACE INHIBITORS

IPC classification:
C07D 213/79, C07D 213/803, C07D 213/85, C07D 241/24, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP14720956

C-LINKED HETEROCYCLOALKYL SUBSTITUTED PYRIMIDINES AND THEIR USES

IPC classification:
A61K 31/506, A61P 25/16, A61P 25/28, C07D 401/14, C07D 403/14, C07D 405/14, C07D 471/04, C07D 493/08
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP14791795

BIHETEROARYL COMPOUNDS AND USES THEREOF

IPC classification:
A61K 31/444, A61K 31/506, A61P 25/00, A61P 25/14, A61P 25/16, A61P 25/18, A61P 25/28, C07D 401/14, C07D 403/14
Applicant:
F. Hoffmann-La Roche SA
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP10784804

TETRAHYDROQUINOLINE INDOLE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS

IPC classification:
A61K 31/4709, A61P 25/24, C07D 401/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP11711074

ARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES

IPC classification:
A61K 31/5517, A61P 15/12, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP11748683

BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES

IPC classification:
A61K 31/381, A61K 31/40, A61K 31/4155, A61K 31/422, A61K 31/4245, A61K 31/427, A61K 31/4418, A61P 3/10, C07D 207/00, C07D 207/10, C07D 213/16, C07D 231/14, C07D 233/26, C07D 263/34, C07D 275/02
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION REFUSED
EP11724168

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/52, C07D 403/14, C07D 473/16
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP11714564

HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES AS VASOPRESSIN V1A RECEPTOR ANTAGONISTS

IPC classification:
A61K 31/5517, A61P 5/24, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP14750486

V1A ANTAGONISTS TO TREAT PHASE SHIFT SLEEP DISORDERS

IPC classification:
A61K 31/5517, A61P 25/00
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP11768005

ILK GENE AS MARKER FOR ERLOTINIB TREATMENT

IPC classification:
C07D 239/94, G01N 33/50, G01N 33/574
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP10790920

AMINO OXAZINE DERIVATIVES

IPC classification:
A61K 31/5355, A61P 3/10, C07D 265/08, C07D 413/12, C07D 417/12, C07D 495/04, C07D 498/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP12703325

1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/553, A61P 25/00, C07D 267/10, C07D 413/12, C07D 417/14
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP12701922

N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/5365, A61P 25/28, C07D 498/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
PATENT GRANTED
EP14789286

CRYSTALLINE FORMS OF A PYRROLIDONE DERIVATIVE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE AND PREPARATION THEREOF

IPC classification:
C07D 207/273
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP11739092

1,4,5,6-TETRAHYDRO-PYRIMIDIN-2-YLAMINE COMPOUNDS

IPC classification:
A61K 31/513, A61P 3/10, C07D 239/22, C07D 239/70, C07D 403/12, C07D 405/12, C07D 409/12, C07D 413/12, C07D 417/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP11715545

HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES

IPC classification:
A61K 31/5517, A61P 1/16, A61P 9/04, A61P 9/12, A61P 13/12, A61P 15/10, A61P 25/00, A61P 25/18, A61P 25/22, A61P 25/24, C07D 487/04, C07D 519/00
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
NO OPPOSITION FILED WITHIN TIMELIMIT
EP14800010

TETRAHYDRO-BENZODIAZEPINONES

IPC classification:
A61K 31/551, A61P 35/00, C07D 243/12, C07D 401/06, C07D 401/14, C07D 403/06, C07D 403/12, C07D 405/06, C07D 405/14, C07D 413/06, C07D 417/12, C07D 487/08
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP12700341

1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS

IPC classification:
A61K 31/5375, A61K 31/5377, A61P 3/10, C07D 265/30, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP16155153

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

IPC classification:
A61K 31/52, C07D 403/14, C07D 473/16
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Genentech, Inc.
Agent:
Sam Rogerson Bailey, Mewburn Ellis LLP
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP14805290

SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1 -[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF

IPC classification:
A61K 31/5517, A61P 25/00, C07D 487/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP14821614

PYRAZOLE DERIVATIVES AND USES THEREOF AS INHIBITORS OF DLK

IPC classification:
A61K 31/4439, A61P 25/00, C07D 401/04, C07D 401/14, C07D 405/14, C07D 413/14, C07D 471/04, C07D 487/04, C07D 491/08, C07D 491/107, C07D 498/04, C07D 498/10
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP14815318

SPIRO-OXAZOLONES

IPC classification:
A61K 31/438, A61P 25/00, C07D 491/10, C07D 491/12, C07D 498/10
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP14821587

5-ARYL-1-IMINO-1-OXO-[1,2,4]THIADIAZINES

IPC classification:
A61K 31/549, A61K 31/554, A61P 25/28, C07D 513/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP15702398

FLUORO-NAPHTHYL DERIVATIVES

IPC classification:
C07D 213/56, C07D 213/61, C07D 309/14, C07D 401/04, C07D 405/12, C07D 405/14
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP10785437

2-AMINO-5,5-DIFLUORO-5,6-DIHYDRO-4H-OXAZINES AS BACE 1 AND/OR BACE 2 INHIBITORS

IPC classification:
A61K 31/535, A61K 31/5355, C07D 265/08, C07D 413/12
Applicant:
F. Hoffmann-La Roche AG
Applicant:
Siena Biotech Spa
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
APPLICATION DEEMED TO BE WITHDRAWN
EP15706198

SPIRO-OXAZOLONES

IPC classification:
A61K 31/443, C07D 491/107, C07D 491/20
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION IN PROGRESS
EP15711118

PIPERIDINE-DIONE DERIVATIVES

IPC classification:
A61K 31/4453, A61K 31/4545, A61P 35/00, C07D 401/04, C07D 401/14, C07D 409/04, C07D 409/14, C07D 417/04, C07D 417/14, C07D 487/08, C07D 491/048, C07D 491/08, C07D 491/107
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP15741532

PYRIDYL-TRIAZABICYCLES

IPC classification:
A61K 31/549, A61P 25/00, C07D 417/04, C07D 513/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP15748252

2,2,2-TRIFLUOROETHYL-THIADIAZINES

IPC classification:
A61K 31/54, A61K 45/06, C07D 403/12
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
EXAMINATION REQUESTED
EP15775694

BACE1 INHIBITORS

IPC classification:
A61K 31/542, A61K 31/554, A61P 25/28, C07D 513/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
Request for examination was made
EP15787212

BACE1 INHIBITORS

IPC classification:
A61K 31/542, A61P 25/28, C07D 513/04
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
Request for examination was made
EP15791654

SPIRO-THIAZOLONES

IPC classification:
A61K 31/438, A61P 25/00, C07D 491/107, C07D 491/20
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
Request for examination was made
EP15800821

PEPTIDES

IPC classification:
C07K 7/08
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
Request for examination was made
EP15800822

PEPTIDES

IPC classification:
C07K 7/08
Applicant:
F. Hoffmann-La Roche AG
Agent:
Simona Müller-Afraz, F. Hoffmann-La Roche AG
Status:
Request for examination was made

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